A longer-lasting frown line treatment

Did you know that the longer you relax your expression lines, the smoother they will become? Do you love Botox® or Dysport®, but wish your love would be longer lasting? DAXXIFY® is the only peptide-powered frown line treatment that is long-lasting. Allow more time to reduce your lines!

DAXXIFY before treatment

Before

DAXXIFY results after 2 weeks treatment

2 weeks

DAXXIFY results after 6 months

6 months

DAXXIFY results after 9 months

9 months

ABOUT DAXXIFY®

What is DAXXIFY®?

DAXXIFY® is FDA approved to smooth moderate to severe lines between the brows. It is the only long-lasting frown line treatment powered by a peptide up to a median duration of 6 months and 9 months for some.*

The active ingredient in DAXXIFY® is a purified protein called botulinum toxin type A.

Conventional injectables last 3 – 4 months and require up to 4 treatments a year to maintain results.

Nearly 90% of patients say they wish results lasted longer. With DAXXIFY® you can keep your frown lines smoother for a full year with as few as 2 treatments.*

* At least 50% of patients in clinical studies had no or minor frown lines 6 months after treatment. Between 3% and 5% of patients in clinical studies had no or minor frown lines 9 months after treatment. In other safety studies, between 5% and 17% of patients still had noticeable improvement 9 months later.

Image of a DAXXIFY bottle

Why are peptides important?

All frown line treatments require a special ingredient to stabilize botulinum toxin A, the protein responsible for helping smooth moderate to severe frown lines. For instance, BOTOX® Cosmetic uses human serum albumin (HSA), a blood product, as its stabilizer. Dysport®, another frown line treatment, uses HSA as a stabilizer and cow’s milk protein as a protectant.

DAXXIFY® is unique because it is the only formulation that uses a novel peptide as a stabilizer and does not contain human or animal byproducts.

Is DAXXIFY® safe and well studied?

DAXXIFY® was studied in the largest-ever clinical study conducted for a frown line treatment and included more than 2,400 people across different ages and skin types.

  • There were no serious treatment-related side effects in clinical trials for DAXXIFY®
  • The active ingredient in DAXXIFY® is botulinum toxin type A, an ingredient that has been used in frown line treatments for more than 20 years
  • 96% of people treated with DAXXIFY® were satisfied with their results ?

? 96% of patients reported they were satisfied on a 7-point scale when evaluated at 4 weeks in clinical studies.

DAXXIFY™ may cause serious side effects that can be life threatening. Get medical help right away if you have any of these problems any time (hours to weeks) after injection of DAXXIFY™:

• Problems swallowing, speaking, or breathing due to weakening of associated muscles can be severe and result in loss of life. You are at the highest risk if these problems are pre-existing before injection. Swallowing problems may last for several months.

• Spread of toxin effects. The effect of botulinum toxin may affect areas away from the injection site and cause serious symptoms that include loss of strength and all-over muscle weakness, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, and trouble swallowing.

Do not receive DAXXIFY™ if you are allergic to any of the ingredients in DAXXIFY™ (see Medication Guide for ingredients); had an allergic reaction to any other botulinum toxin product such as rimabotulinumtoxinB (MYOBLOC®), onabotulinumtoxinA BOTOX®/BOTOX® Cosmetic), abobotulinumtoxinA (DYSPORT®), incobotulinumtoxinA (XEOMIN®) or prabotulinumtoxinA-xvfs (JEUVEAU®); or have a skin infection at the planned injection site.

DAXXIFY™ dosing units are not the same as, or comparable to, any other botulinum toxin product.

Tell your healthcare provider about all your medical conditions, including any side effects from botulinum toxin products, including dry eye; breathing, swallowing, bleeding, or heart problems; plans to have surgery; weakness of forehead muscles; drooping eyelids; have had surgery on your face; are pregnant or breastfeeding or plan to become pregnant or breastfeed.

Tell your healthcare provider about all the medicines you take, including prescription and over-thecounter medicines, vitamins, and herbal supplements.

Using DAXXIFY™ with certain other medicines may cause serious side effects. Do not start any new medicines until you have told your healthcare provider that you have received DAXXIFY™ in the past.

Especially tell your healthcare provider if you have received any other botulinum toxin product in the last 4 months or any in the past, and exactly which product you received (such as BOTOX®, BOTOX® Cosmetic, MYOBLOC®, DYSPORT®, XEOMIN®, or JEUVEAU®). DAXXIFY™ may cause serious side effects, including allergic reactions (such as itching, rash, redness, swelling, wheezing, trouble breathing, or dizziness or feeling faint), heart problems (such as irregular heartbeat and heart attack), and eye problems (including dry eye, reduced blinking, and corneal problems). Tell your healthcare provider or get medical help right away if you experience a serious side effect. No serious adverse events of distant spread of toxin effect associated with dermatologic use of DAXXIFY™ have been reported in clinical studies at the dose of 40 Units for glabellar lines. The most common side effects of DAXXIFY™ include headache, eyelid drooping, and loss of ability to move the muscles in your face.

These are not all the possible side effects of DAXXIFY™. For more information, see the full Prescribing Information including Boxed Warning, and refer to the Medication Guide or talk with your doctor. To report side effects associated with DAXXIFY™, please call 1-877-373-8669. You may also report side effects to the FDA at 1-800-FDA-1088 or visit www.fda.gov/medwatch.

APPROVED USE

DAXXIFY™ is a prescription medicine that is injected into muscles and used in adults to temporarily improve the look of moderate to severe frown lines between the eyebrows.

DAXI-001723

You may see results with DAXXIFY® as early as the next day after treatment, and typically within two days.

Several factors contribute to the formation of facial lines. Decreased collagen production, cellular changes, genetics, environmental damage, and sun damage may all play a role.

Facial lines are also formed by repeated muscle contractions such as frowning, squinting, or raising the eyebrows. These facial expressions cause the skin to furrow and fold, which eventually leads to the formation of wrinkles.

DAXXIFY® works below the skin’s surface to temporarily reduce the underlying muscle activity responsible for moderate to severe frown lines.

DAXXIFY® minimizes the appearance of moderate to severe frown lines by temporarily relaxing the underlying muscles that cause these wrinkles. DAXXIFY® is a long-lasting botulinum type A treatment with a novel peptide.

Facial fillers, also known as dermal fillers, are typically made of hyaluronic acid and are used to add volume, fullness, and structure to areas of the face. They can help contour cheekbones, soften lines around the nose and mouth, and volumize lips. Dermal fillers target volume loss rather than muscle-related wrinkles.

If you’re like most people, you probably get a frown line treatment around twice a year. But here’s the thing: conventional treatments only last 3–4 months. If you are not able to get treated every 3-4 months, that means you may spend the next 2-3 months of the year with those frown lines staring back at you between treatments. That’s up to 4-6 months per year without optimal results!

DAXXIFY® is different. With those same 2 treatment visits, you can keep your frown lines smoother for a full year! ?

? At least 50% of patients in clinical studies had no or minor frown lines 6 months after treatment.

DAXXIFY® is manufactured in California, and the only prescription frown line treatment made in the United States. Conventional frown line treatments are manufactured in other countries, then imported into the United States.

In 2002, physicians and entrepreneurs founded a start-up in Silicon Valley, California to explore the use of peptides in biologics for different therapeutic uses. Their goal was to utilize peptides to transport biologics, typically large molecules, through the skin.

The initial idea was to formulate botulinum toxin type A, the active ingredient in DAXXIFY®, with a peptide to see if it could be applied topically to the skin to treat crow’s feet wrinkles. Through this process, scientists discovered that the formulation was optimally administered through injection. Several clinical studies were created to determine the correct dose for an injectable product that would treat frown lines.

In clinical studies, DAXXIFY® lasted on average 6 months and up to 9 months for some people.‡ It is the only treatment of its kind formulated with a peptide.

‡At least 50% of patients in clinical studies had no or minor frown lines 6 months after treatment. Between 3% and 5% of patients in clinical studies had no or minor frown lines 9 months after treatment. In other safety studies, between 5% and 17% of patients still had noticeable improvement 9 months later.

Like DAXXIFY®, BOTOX® Cosmetic, DYSPORT®, XEOMIN® and JEUVEAU® are also Botulinum Toxin A products FDA-approved for cosmetic use. DAXXIFY® is a product of Revance, BOTOX® Cosmetic is a product of Allergan, Dysport® is a product of Galderma, XEOMIN® is a product of Merz Aesthetics, and JEUVEAU®, a product of EVOLUS.

Schedule Your Daxxify Consultation With Dr. Lum in Torrance, CA

Lumier Medical proudly serves patients throughout Los Angeles County, including Torrance, Redondo Beach, Palos Verdes, Manhattan Beach, Hermosa Beach, and Rolling Hills Estates. Our Torrance clinic is a convenient South Bay destination for physician-led, natural-looking aesthetic care—without the Beverly Hills commute.

Interested in longer-lasting wrinkle reduction with Daxxify? Contact Dr. Michael Lum at Lumier Medical to schedule your consultation today and receive a personalized, conservative treatment plan designed for natural results.

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